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-synuclein, which can be a most important component of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) strain, advise that dysfunction on the intracellular proteinase programs, for example ubiquitin-proteasome method or lysosomal program, which removes poi